The 'Nobody is born cool' meme originates from a memorable scene in the animated film The Incredibles, where the character Syndrome, voiced by Jason Lee, is seen driving a car. In this meme, Syndrome's act of tossing someone out of the car humorously illustrates the rejection of everything that's not deemed 'cool,' save for a specific exception. The meme plays on Syndrome's villainous yet quirky personality, using his exaggerated gestures to create a hilarious contrast between what's universally rejected and what's given a rare stamp of approval.