The meme originates from a memorable scene in the TV series "Blue Mountain State," where the character Harmon Tedesco, played by James Cade, finds himself in a tricky situation. Harmon, who is known for his less-than-innocent antics, attempts to pass off cocaine as medicinal, displaying an amusing level of confidence in his lies. This scene is classic for its comedic take on someone trying to maintain a facade of professionalism or innocence while clearly being caught red-handed. It's this blend of panic and comedic timing that catapulted this moment into meme fame, as viewers resonate with the hilarity of being caught in a lie.