The meme originates from the popular video game Grand Theft Auto: San Andreas, specifically featuring the character Carl "CJ" Johnson, who is voiced by actor Young Maylay. In the opening mission of the game, CJ finds himself back in his old neighborhood, muttering the now-iconic line, "Ah shit, here we go again," as he begins another turbulent journey through the crime-ridden streets of Los Santos. This line quickly became emblematic in the gaming community for its relatability and the sense of inevitable repetition, capturing the essence of facing an all-too-familiar challenge yet again.