The meme originates from a memorable scene in the 2012 comedy film "Ted," directed by Seth MacFarlane. In this scene, Ted, the foul-mouthed teddy bear voiced by MacFarlane, and his best friend John, played by Mark Wahlberg, engage in a hilariously chaotic rant about F. Scott Fitzgerald in an attempt to impress a girl. The scene captures the essence of unfiltered and somewhat absurd male camaraderie, making it a prime candidate for memes that highlight the dynamic between two friends who share one chaotic brain cell.