The 'Does he bite?' meme comes from a four-panel comic strip, where the humor lies in the unexpected punchline. The setup involves a simple question about a dog's biting habits, answered with a twist that the dog inflicts emotional rather than physical harm. This comic cleverly uses the dog's innocent appearance to set up a humorous contradiction, where the real "bite" comes from an emotional gut-punch, often due to the dog's sheer adorableness or the cuteness overload. It's a classic bait-and-switch scenario that taps into familiar experiences, making it a favorite for meme creators.