The "Dexter big facts book" meme originates from the beloved 90s cartoon "Dexter's Laboratory," which follows the adventures of a boy genius named Dexter. Known for his secret lab and penchant for science, Dexter is a character synonymous with overconfidence and curiosity. The meme features a scene where Dexter excitedly holds a giant red book labeled "FACTS," only to be shown later holding blank pages, sweating and defeated. This visual gag humorously illustrates a common occurrence where one's confidence is undercut by the stark reality, a situation many find relatable in both academic and personal contexts.