The 'Agree to Disagree' meme template featuring red, blue, and yellow characters originates from the comic strips created by Safely Endangered, a popular webcomic series known for its humorous take on everyday situations. The characters, affectionately known as 'bonhommes,' are simplistic humanoid figures that express a wide range of emotions and situations. This particular meme format captures a moment where two characters, often depicted in contrasting colors like red and blue, engage in a heated argument, leading to a reluctant handshake, symbolizing the phrase "agree to disagree." This simple yet expressive template has become a staple for illustrating the humorous side of unresolved disagreements.