The Zac Efron and Dave Franco handshake meme originates from a scene where the two actors share an elaborate and heartfelt handshake, followed by a hug and a forehead kiss, all set to emotional music. This scene is typically characterized by its over-the-top expression of 'bro love,' making it ripe for meme culture. The dramatic farewell is reminiscent of epic cinematic goodbyes, but it's applied to everyday situations, turning the mundane into something hilariously sentimental. Efron and Franco's comedic chemistry, showcased in films like "Neighbors," adds an extra layer of humor and relatability to the meme.