The "Leo and Toby" meme features a memorable scene of Leonardo DiCaprio and Tobey Maguire interacting with each other in a dramatic farewell. This setup is typically accompanied by the melancholic tune of "Where Is My Mind" by the Pixies, adding to the emotional weight of the moment. These two actors, who are real-life friends, often capture the public's imagination with their off-screen camaraderie. The meme typically shows them acknowledging each other before parting ways, which mirrors the universal experience of saying goodbye. It's a visual metaphor for those poignant life transitions, infused with a touch of Hollywood glamour and nostalgia.