The 'Interstellar flashback' meme takes its roots from the critically acclaimed sci-fi film 'Interstellar,' directed by Christopher Nolan. The specific scene in question involves Matthew McConaughey’s character, Cooper, desperately trying to communicate across time to prevent a disastrous decision. His emotional outburst and helplessness as he watches events unfold make it an iconic moment perfectly suited for expressing regret. This scene has been meme-ified due to its dramatic depiction of hindsight and the universal desire to alter past choices.