The meme featuring Robert De Niro, known for his iconic roles in movies like "Goodfellas" and "Taxi Driver," originates from a scene where he is seen sitting at a dimly lit bar in a gray suit, holding a drink and looking directly at the camera. His stern and accusatory expression, combined with the ambiance of the scene, provides a perfect backdrop for memes centered on moral outrage and disbelief. The image has been repurposed to capture the feeling of incredulity when someone finds humor in a situation that seems anything but funny. This combination of De Niro's serious demeanor with the absurdity of someone's inappropriate reaction is what makes the meme so relatable and widely used.